![]() We also review recent advances regarding the molecular nature of DV patterning, including the initiation of the DV axis, the formation of the BMP gradient, and the regulatory molecular mechanisms behind BMP signaling during the establishment of the DV axis. Throughout, we focus specifically on popular model animals, such as Xenopus and zebrafish, highlighting the similarities and differences of the regulatory networks between species. In this review, we summarize the current knowledge of the function and regulation of BMP signaling in DV patterning. Multiple lines of genetic, molecular, and embryological evidence have suggested that numerous BMP signaling components and their attendant regulators act in concert to shape the developing DV axis. ![]() Interestingly, the embryonic DV axis exhibits robust stability, even in face of variations in BMP signaling. This is a remarkable regulatory and evolutionary feat, as the BMP gradient has been maintained despite the tremendous variation in embryonic size and shape across species. The regulation of BMP signaling during DV patterning has been strongly conserved across evolution. It is well-known that the morphogen gradient created by BMP signaling activity is crucial for DV axis patterning across a diverse set of vertebrates. One of the most significant events during early embryonic development is the establishment of a basic embryonic body plan, which is defined by anteroposterior, dorsoventral (DV), and left-right axes. 6Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.5State Key Laboratory of Membrane Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China.4Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.3Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China. ![]() 2National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. ![]()
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